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M94A3122.TXT
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1994-10-25
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Document 3122
DOCN M94A3122
TI Herpesvirus antibodies levels in HIV2 positive population.
DT 9412
AU Marques A; Palminha P; Graca A; National Institute of Health, Lisbon,
Portugal.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):149 (abstract no. PB0024). Unique
Identifier : AIDSLINE ICA10/94369453
AB The importance of Herpesvirus (Epstein-Barr Virus, Citomegalo Virus,
Herpes Simplex Virus, Varicella zoster Virus) infections in the acquired
immunodeficiency syndrome is not well established. A study of the
serological profiles against Herpesvirus was carried out in HIV2 samples
of patients attending an out-patient clinic. Forty-two HIV2 positives
cases were distributed by signs and symptoms; 27 (64%) asymptomatic, 15
(36%) symptomatic. The distribution by race and sex showed that 28 (67%)
black, 14 (33%) caucasian, 27 (64%) males, 15 (36%) females. The
following age groups were identified, 10-19 years 2 cases (5%), 20-29
years 10 cases (24%), 30-39 years 7 cases (17%), 40-49 years 15 cases
(37%), 50-59 years 4 cases (10%) and over 60 years 3 cases (7%). At the
Laboratory of Virology of the National Institute of Health sera samples
were titrated using the indirect immunofluorescence assays. Most sera
had IgG anti-EBV antibodies (96%), IgG anti-CMV antibodies (93%), IgG
anti-HSV antibodies (100%), IgG anti-VZV antibodies (95%) and all the
96% IgG anti-EBV had IgG anti-Epstein-Barr Nuclear Antigen (EBNA)
positives. Concerning the IgM antibodies we found two cases of IgM
anti-EBV positives and one case of IgM anti-CMV positive. High titres
were observed for the following virus: EBV, 1/160 12 cases (29%), 1/320
16 cases (38%), 1/640 7 cases (17%): CMV, 1/40 12 cases (29%), 1/80 13
cases (31%), 1/160 8 cases (19%); HSV, 1/160 17 cases (41%), 1/320 16
cases (38%), 1/640 7 cases (17%); VZV 1/20 9 cases (21%), 1/40 15 cases
(36%), 1/80 11 cases (28%). The two cases of IgM anti-EBV antibodies
positives, one had a IgG titre 1/160 and the other had a IgG titre
1/320. The case with IgM anti-CMV antibodies positives had a IgG titre
1/160. We found higher titres for the antibodies anti-EBV and anti-HSV
than those found in the portuguese population in general. Additionally
the titres of IgG antibodies anti-CMV and anti-VZV were similar to those
found in the general population. In summary we don't know if the
presence of high levels of these antibodies for the EBV and HSV are due
to the reactivation of the virus or are markers or cofactors in the
development of severe disease.
DE Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY Adolescence Adult
Antibodies, Viral/*BLOOD Child Comparative Study
Cytomegalovirus/*IMMUNOLOGY Female Herpesvirus 4, Human/*IMMUNOLOGY
Human HIV Seropositivity/BLOOD/*IMMUNOLOGY *HIV-2 IgG/BLOOD
IgM/BLOOD Male Middle Age Portugal Simplexvirus/*IMMUNOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).